[Effects of Dan-Chuan-Hong decoction on myocardial apoptosis of acute myocardial ischemia in rats].

Abstract

OBJECTIVE:

To observe the effects of Dan-Chuan-Hong decoction on myocardial apoptosis of acute myocardial ischemia in rats.

METHODS:

Rats received Guan-Xin-Er-Hao, Dan-Chuan-Hong or normal saline at 30 minutes before ischemia. The model of acute myocardial infarction (AMI) in rats was set up by ligating the descending branch of left coronary artery. 3 hours after AMI, the hearts were isolated to detect the apoptosis of myocardial ischemia by TUNEL; 24 hours after AMI, the hearts were isolated to determine the area of myocardial infarction by quantitative histological assay (triphenyltetrazolium chloride, TTC stain).

RESULTS:

Comparing with model group,the myocardial infarct size and apoptosis index of all the treatment groups decreased. Comparing with Guan-Xin-Er-Hao (30 g/kg) or Dan-Chuan-Hong (10 g/kg), the myocardial infarct size and apoptosis index of Dan-Chuan-Hong (20 g/kg) had no statistic difference. And there was statistic difference between Guan-Xin-Er-Hao (30 g/kg)and Dan-Chuan-Hong (10 g/kg).

CONCLUSION:

Comparing with Guan-Xin-Er-Hao, the decoction of Dan-Chuan-Hong has similar effect, which could protect hearts from myocardial ischemia by inhibiting the myocardial apoptosis.

• Authors: Xiao-Yu Wang, Feng Qin, Xi Huang, Xue-Ya Zhang, Ping Ren, Hong-Wei Zhao
• Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (Zhong Yao Cai) Vol. 32 Issue 5 Pg. 725-8 (May 2009) ISSN: 1001-4454 [Print] China
• PMID: 19771846 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Combinations
• Drugs, Chinese Herbal
• guan xin II

Topics

• Acute Disease
• Animals
• Apiaceae (chemistry)
• Apoptosis (drug effects)
• Carthamus tinctorius (chemistry)
• Disease Models, Animal
• Drug Combinations
• Drugs, Chinese Herbal (isolation & purification, pharmacology, therapeutic use)
• Male
• Myocardial Infarction (drug therapy, pathology, prevention & control)
• Myocardial Ischemia (drug therapy, pathology, prevention & control)
• Myocardium (pathology)
• Plants, Medicinal (chemistry)
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Salvia miltiorrhiza (chemistry)