Twenty five years follow up of MB leprosy patients retreated with a modified MDT regimen after a full course of dapsone mono-therapy.

Abstract

BACKGROUND:

The relentless emergence of dapsone resistance amongst M. leprae threatened leprosy control programmes, and increased the relapse rate of patients cured with dapsone monotherapy.

OBJECTIVE:

The study aimed to analyse the effect on the relapse rate of dapsone-cured multibacillary (MB) leprosy patients, of re-treatment, using a multidrug therapy (MDT) regimen which differed from the WHO recommended regimen.

DESIGN:

794 MB leprosy patients who had been released from treatment after dapsone monotherapy were selected, amongst them 657 were re-treated for 1 year using the modified multidrug therapy regimen (mMDT) including rifampicin, clofazimine and dapsone, and 137 patients were observed as control cases.

RESULTS:

The regimen was well tolerated with good compliance: 620 patients completed re-treatment with mild side effects and a low incidence of leprosy reactions. There was a statistically significant difference between the relapse rates of re-treated and control groups (chi squaredf = 57.44, P < 0.001). Furthermore, the relapses in the re-treated group were significantly more likely to be later than those in the control group (t = 25.62, P < 0.001).

CONCLUSIONS:

Re-treatment with this modified regimen is acceptable and can reduce the risk of early relapse in dapsone-cured patients. The problem of persisters causing late relapse is likely to remain.

• Authors: Zhichun Jing, Renbao Zhang, Doahai Zhou, Jiakeun Chen
• Journal: Leprosy review (Lepr Rev) Vol. 80 Issue 2 Pg. 170-6 (Jun 2009) ISSN: 0305-7518 [Print] England
• PMID: 19743621 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Leprostatic Agents
• Dapsone

Topics

• Adolescent
• Adult
• Aged
• Anti-Bacterial Agents (adverse effects, therapeutic use)
• Dapsone (adverse effects, therapeutic use)
• Drug Therapy, Combination
• Female
• Follow-Up Studies
• Humans
• Leprostatic Agents (therapeutic use)
• Leprosy (drug therapy)
• Male
• Middle Aged
• Patient Compliance (statistics & numerical data)
• Recurrence
• Treatment Outcome
• Young Adult