Adjunctive therapy for intractable epilepsy with ethotoin.

Abstract

In a retrospective study, records of 46 patients (24 women and 22 men aged 17-51 years; mean 29.2 years), who had been treated with ethotoin (EHN) as adjunctive therapy for control of intractable seizures were reviewed. Overall, approximately 51% of this highly selected patient population had a reduction greater than 50% in overall seizure frequency 1 month after initiation of treatment. This was reduced to approximately 25% for the last 3 months of follow-up (mean follow-up period 10.6 months). Tonic seizure frequency was reduced most dramatically, by greater than 50%, in 60% of patients at 1 month and in 35% of patients for the last 3 months of follow-up. This study suggests that prospective controlled trials of EHN, especially for tonic seizures, are needed.

• Authors: V Biton, J R Gates, F J Ritter, R B Loewenson
• Journal: Epilepsia (Epilepsia) 1990 Jul-Aug Vol. 31 Issue 4 Pg. 433-7 ISSN: 0013-9580 [Print] United States
• PMID: 1973383 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Hydantoins
• Phenytoin

Topics

• Adolescent
• Adult
• Epilepsy (drug therapy)
• Female
• Humans
• Hydantoins (therapeutic use)
• Male
• Middle Aged
• Phenytoin (therapeutic use)
• Retrospective Studies