Use of luteinizing-hormone-releasing hormone nasal spray in the treatment of cryptorchidism: is there still an indication? A clinical study in 78 boys with 103 undescended testicles.

Abstract

We treated 78 boys with 103 undescended testicles with luteinizing-hormone-releasing hormone (LHRH) nasal spray, 400 micrograms 3 times daily for 4 weeks. After one (28 testicles) or two (5 testicles) courses of LHRH, 33 testicles in 25 boys were in the normal scrotal position. The success rate is 32%. In 41 testicles (40%) the result was a better mobility and/or a further descent, facilitating the proper diagnosis or the operation. 70 testicles were operated, and anatomic abnormalities were seen 37 times. In 6 boys minor side effects were noted. Reviewing the literature there is agreement that LHRH spray sometimes is necessary to confirm the presence of a retractile testicle, and so can be used in trying to avoid an operation.

• Authors: J A Witjes, J D de Vries, M T Lock, F M Debruyne
• Journal: European urology (Eur Urol) Vol. 17 Issue 3 Pg. 226-8 ( 1990) ISSN: 0302-2838 [Print] Switzerland
• PMID: 1972065 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Gonadotropin-Releasing Hormone

Topics

• Administration, Intranasal
• Child
• Combined Modality Therapy
• Cryptorchidism (drug therapy, surgery)
• Gonadotropin-Releasing Hormone (administration & dosage, therapeutic use)
• Humans
• Male