[Long-term efficacy of deep brain stimulation in patients with dystonia].

Abstract

In patients with primary generalized or segmental dystonia controlled studies have shown that bilateral pallidal deep brain stimulation (DBS) can reduce disability scores by 40 to 60 %. Up to now, the data base on the therapeutic effects of DBS in selected patients with focal dystonia is less extensive. Long-term efficacy of DBS in dystonia has been demonstrated, but reports have focused mainly on patients with primary generalized dystonia so far, with a mean observation period of approximately 5 years. Predictors of a favourable long-term efficacy of DBS in primary generalized dystonia patients are young age at surgery, a shorter duration of the disease, a lower severity of disability, and a posteroventrolateral localization of the DBS electrode within the globus pallidus internus (GPi). Controlled studies are needed to identify also the factors determining the best long-term outcome of non-generalized dystonia patients treated with DBS.

• Authors: A Wolters
• Journal: Fortschritte der Neurologie-Psychiatrie (Fortschr Neurol Psychiatr) Vol. 77 Suppl 1 Pg. S61-3 (Aug 2009) ISSN: 1439-3522 [Electronic] Germany
• Vernacular Title: Langzeiteffekte der tiefen Hirnstimulation bei Dystonie-Patienten.
• PMID: 19685397 (Publication Type: English Abstract, Journal Article, Review)
• Copyright: (c) Georg Thieme Verlag KG Stuttgart-New York.

Topics

• Deep Brain Stimulation (instrumentation)
• Disability Evaluation
• Dystonia (therapy)
• Electrodes, Implanted
• Globus Pallidus (physiology)
• Humans
• Treatment Outcome