Abstract |
Epistasis, the interaction between genes, is a topic of current interest in molecular and quantitative genetics. We have further studied a previously investigated sample of 187 major depressive disorder (MDD) patients, 171 bipolar disorder (BD) patients, and 288 controls, and tried to analyze the interaction between a set of variations of independent genes: the trace amine receptor 6 (rs4305745, rs8192625, rs7452939, rs6903874, and rs6937506) and the heat shock protein 70 (rs562047, rs1061581, rs2227956). The multifactor dimensionality reduction (MDR) method was applied and the covariates associated with diagnosis were also controlled. A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders. The level of statistical significance (P < 0.001) and the testing balancing accuracy over 0.62 suggest a cautious optimism toward this result, although the possibility of false positivity warrants further analyses in independent samples.
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Authors | Chi-Un Pae, Antonio Drago, Martina Forlani, Ashwin A Patkar, Alessandro Serretti |
Journal | American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
(Am J Med Genet B Neuropsychiatr Genet)
Vol. 153B
Issue 2
Pg. 680-683
(Mar 05 2010)
ISSN: 1552-485X [Electronic] United States |
PMID | 19582769
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | (c) 2009 Wiley-Liss, Inc. |
Chemical References |
- Cell Cycle Proteins
- HSP70 Heat-Shock Proteins
- Nuclear Proteins
- Receptors, G-Protein-Coupled
- trace amine receptor 4, human
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Topics |
- Alleles
- Case-Control Studies
- Cell Cycle Proteins
(genetics)
- Depressive Disorder, Major
(genetics)
- Epistasis, Genetic
- Genetic Variation
- HSP70 Heat-Shock Proteins
(genetics)
- Heterozygote
- Homozygote
- Humans
- Models, Genetic
- Mood Disorders
(genetics)
- Nuclear Proteins
(genetics)
- Receptors, G-Protein-Coupled
- Reproducibility of Results
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