Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: AIM OF THE STUDY: To evaluate this traditional information, anti-inflammatory and antinociceptive activities of the methanolic and aqueous extracts prepared from different parts (stem, fruit and leaves) of the five Turkish taxa under Juniperus section of the gender; J. drupacea, J. communis var. communis, J. communis var. saxatilis, J. oxycedrus subsp. oxycedrus, and J. oxycedrus subsp. macrocarpa growing were investigated. METHODS: For the anti-inflammatory activity, carrageenan-induced and PGE(2)-induced hind paw edema models, and for the antinociceptive activity p-benzoquinone-induced writhing and hot plate tests in mice were employed. RESULTS: The methanolic extracts of fruit and leaves from J. oxycedrus subsp. oxycedrus and J. communis var. saxatilis exhibited notable inhibition in carrageenan-induced edema model at a dose of 100mg/kg. The same extracts also displayed significant activity against PGE(2)-induced edema model. While, the remaining extracts were found inactive against these edema models. A similar activity pattern was observed against p-benzoquinone-induced abdominal constriction test without inducing any gastric damage or apparent acute toxicity, whereas all extracts were inactive in hot plate test. CONCLUSION: The experimental data demonstrated that J. oxycedrus subsp. oxycedrus and J. communis var. saxatilis displayed remarkable anti-inflammatory and antinociceptive activities; however, further studies are warranted to define and isolate the active anti-inflammatory and antinociceptive components from these active species which may yield safe and effective agents to be used in the treatment of inflammatory disorders.
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Authors | Esra Küpeli Akkol, Ayşegül Güvenç, Erdem Yesilada |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 125
Issue 2
Pg. 330-6
(Sep 07 2009)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 19505566
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Analgesics
- Anti-Inflammatory Agents
- Benzoquinones
- Plant Extracts
- quinone
- Carrageenan
- Dinoprostone
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Topics |
- Analgesics
(pharmacology, therapeutic use)
- Animals
- Anti-Inflammatory Agents
(pharmacology, therapeutic use)
- Behavior, Animal
(drug effects)
- Benzoquinones
- Carrageenan
- Dinoprostone
- Edema
(chemically induced, drug therapy)
- Inflammation
(drug therapy)
- Juniperus
- Male
- Mice
- Pain
(chemically induced, drug therapy)
- Phytotherapy
- Plant Extracts
(pharmacology, therapeutic use)
- Plant Structures
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