Endogenous subclinical hyperthyroidism and cardiovascular system: time to reconsider?

Abstract

Subclinical hyperthyroidism is an increasingly recognized entity that is defined as a normal serum free thyroxine and free triiodothyronine levels with a thyroid-stimulating hormone level suppressed below the normal range and usually undetectable. Exogenous sublinical hyperthyroidism is a thyroid metabolic state caused by L-thyroxine administration. Endogenous subclinical hyperthyroidism is a thyroid metabolic state in patients with autonomously functioning thyroid nodule or multinodular goiter, various forms of thyroiditis, in areas with endemic goiter and particularly in elderly subjects. Endogenous subclinical hyperthyroidism is currently the subject of numerous studies and it yet remains controversial particularly as it relates to its treatment and to cardiovascular impact nevertheless established effects have been demonstrated. Recently, acute myocardial infarction without significant coronary stenoses and recurrent acute pulmonary embolism have been reported associated with subclinical hyperthyroidism without L-thyroxine administration. So, it is very important to recognize and to treat promptly also endogenous subclinical hyperthyroidism.

• Authors: Salvatore Patanè, Filippo Marte, Mauro Sturiale
• Journal: International journal of cardiology (Int J Cardiol) Vol. 149 Issue 1 Pg. 108-9 (May 19 2011) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 19473714 (Publication Type: Letter)
• Copyright: Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.

Topics

• Cardiovascular Diseases (epidemiology)
• Humans
• Hyperthyroidism (epidemiology, therapy)
• Risk Factors
• Severity of Illness Index
• Thromboembolism (epidemiology)