Abstract | BACKGROUND: METHODS: We performed a multicenter, randomized, noninferiority study involving 158 patients from 13 European Group for Blood and Marrow Transplantation centers who were randomly allocated at approximately 100 days after myeloablative stem cell transplantation to receive a series of vaccinations (3 doses of PCV7 given 1 month apart) that was started immediately (i.e., 3 months after transplantation) or 6 months later (i.e., 9 months after transplantation). The primary evaluation criterion was the rate of response (antibody level, > or = 0.15 microg/mL for each of the 7 serotypes) at 1 month after the third dose of PCV7. The noninferiority margin was 20%. All patients were followed up for 24 months after transplantation or until death, whichever occurred first. RESULTS: We found that the response rate was not lower after early vaccination (79% [45 of 57 patients]) than after late vaccination (82% [47 of 57 patients]) (difference, -3.5%; 90% confidence interval, -15.6 to 8.6; not significant). CONCLUSIONS:
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Authors | Catherine Cordonnier, Myriam Labopin, Virginie Chesnel, Patricia Ribaud, Rafael De La Camara, Rodrigo Martino, Andrew J Ullmann, Terttu Parkkali, Anna Locasciulli, Karima Yakouben, Karlis Pauksens, Hermann Einsele, Dietger Niederwieser, Jane Apperley, Per Ljungman, Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 48
Issue 10
Pg. 1392-401
(May 15 2009)
ISSN: 1537-6591 [Electronic] United States |
PMID | 19368505
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Bacterial
- Heptavalent Pneumococcal Conjugate Vaccine
- Immunosuppressive Agents
- Pneumococcal Vaccines
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Topics |
- Adolescent
- Adult
- Antibodies, Bacterial
(blood)
- Child
- Europe
- Female
- Heptavalent Pneumococcal Conjugate Vaccine
- Humans
- Immunization Schedule
- Immunization, Secondary
- Immunosuppressive Agents
(therapeutic use)
- Male
- Middle Aged
- Pneumococcal Vaccines
(administration & dosage, immunology)
- Stem Cell Transplantation
- Time Factors
- Young Adult
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