Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: AIM OF THE STUDY: The effectiveness of extracts, fractions and subfractions from dried Centaurea solstitialis L. subsp. solstitialis (CSS) (Asteraceae) roots and aerial parts were studied on mice. MATERIALS AND METHODS: The antinociceptive and antipyretic effects of Centaurea solstitialis L. subsp. solstitialis have been investigated by using p-benzoquinone-induced writhing reflex for antinociceptive activity and Freund's Complete Adjuvant-induced pyrexia model for antipyretic activity assessment in mice. RESULTS: The ethanolic extract from the aerial parts of the plant was shown to possess significant antinociceptive (p < 0.01) and antipyretic activities (p < 0.01). The extract was then submitted to subsequent solvent extractions and chromatographic processes. Through bioassay-guided fractionation and isolation procedures two sesquiterpene lactones, solstitialin A and acetyl solstitialin, were isolated and defined as the active components of CSS. On the other hand, a comparative study was conducted on another species, Centaurea depressa Bieb., which has no similar folkloric utilization. Following the same fractionation chart same compounds were defined as the active ingredients. CONCLUSION: Results of the present study proved that aerial part of CSS possesses antinociceptive and antipyretic activities supporting the folkloric assertion in Turkish folk medicine. However, these effects seem not limited to CSS, some other Centaurea species, in fact, having no folkloric use might be equally active.
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Authors | Esra Küpeli Akkol, Reyhan Arif, Fatma Ergun, Erdem Yesilada |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 122
Issue 2
Pg. 210-5
(Mar 18 2009)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 19330908
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Benzoquinones
- Lactones
- Plant Extracts
- Sesquiterpenes
- quinone
- Freund's Adjuvant
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Topics |
- Analgesics
(pharmacology, therapeutic use)
- Animals
- Benzoquinones
- Centaurea
(chemistry)
- Fever
(chemically induced, drug therapy)
- Freund's Adjuvant
- Lactones
(pharmacology, therapeutic use)
- Male
- Mice
- Pain
(chemically induced, drug therapy)
- Phytotherapy
- Plant Components, Aerial
- Plant Extracts
(chemistry, pharmacology, therapeutic use)
- Plant Roots
- Sesquiterpenes
(pharmacology, therapeutic use)
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