Abstract | BACKGROUND: Cross-sectional studies have reported an association between major depressive episode ( MDE) and obesity. The objective of this longitudinal analysis was to determine whether MDE increase the risk of becoming obese over a 10-year period. METHOD: We used data from the Canadian National Population Health Survey (NPHS), a longitudinal study of a representative cohort of household residents in Canada. The incidence of obesity, defined as a body mass index (BMI) of > or =30, was evaluated in respondents who were 18 years or older at the time of a baseline interview in 1994. MDE was assessed using a brief diagnostic instrument. RESULTS: CONCLUSIONS:
MDE does not appear to increase the risk of obesity. The cross-sectional associations that have been reported, albeit inconsistently, in the literature probably represent an effect of obesity on MDE risk. Pharmacologic treatment with antidepressants may be associated with an increased risk of obesity, and strategies to offset this risk may be useful in clinical practice.
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Authors | Scott B Patten, Jeanne V A Williams, Dina H Lavorato, Lauren Brown, Lindsay McLaren, Michael Eliasziw |
Journal | Psychotherapy and psychosomatics
(Psychother Psychosom)
Vol. 78
Issue 3
Pg. 182-6
( 2009)
ISSN: 1423-0348 [Electronic] Switzerland |
PMID | 19321971
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2009 S. Karger AG, Basel. |
Chemical References |
- Antidepressive Agents
- Cyclohexanols
- Venlafaxine Hydrochloride
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Topics |
- Adolescent
- Adult
- Aged
- Antidepressive Agents
(adverse effects, therapeutic use)
- Body Mass Index
- Cross-Sectional Studies
- Cyclohexanols
(adverse effects, therapeutic use)
- Depressive Disorder, Major
(drug therapy, epidemiology)
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Obesity
(chemically induced, epidemiology)
- Risk Factors
- Venlafaxine Hydrochloride
- Young Adult
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