Idiopathic hypogonadotropic hypogonadism in selective human gonadotropin deficiency in adult man: a case report.

Abstract

We report a rare case of idiopathic hypogonadotropic hypogonadism in an adult male (31-year-old), who underwent an endocrinological examination because of erectile dysfunction and suspected infertility. Laboratory data showed isolated gonadotropin deficiency. Magnetic resonance imaging (MRI) of the hypothalamic-pituitary unit showed no tumoral expansions. The patient was tested with gonadotropin releasing hormone (Gn-RH) (100 microg as an i.v. bolus injection). No significant LH and FSH responses were observed. Idiopathic hypogonadotropic hypogonadism is usually caused by hypothalamic lesions, however, since Gn-RH was unable to stimulate LH and FSH secretions, we supposed that our patient was affected by defective gonadotropin secretion at pituitary level.

• Authors: Riccardo Volpi, Maria Chiara Ugolotti, Andrea Carbucicchio, Roberto Delsignore
• Journal: Acta bio-medica : Atenei Parmensis (Acta Biomed) Vol. 79 Issue 3 Pg. 251-4 (Dec 2008) ISSN: 0392-4203 [Print] Italy
• PMID: 19260388 (Publication Type: Case Reports, Comparative Study, Journal Article)

Chemical References

• Androgens
• Gonadotropins, Pituitary
• Gonadotropin-Releasing Hormone
• Testosterone
• Luteinizing Hormone
• Follicle Stimulating Hormone

Topics

• Adult
• Androgens (therapeutic use)
• Erectile Dysfunction (etiology)
• Follicle Stimulating Hormone (blood)
• Gonadotropin-Releasing Hormone
• Gonadotropins, Pituitary (deficiency)
• Humans
• Hypogonadism (blood, complications, diagnosis, drug therapy)
• Luteinizing Hormone (blood)
• Male
• Testosterone (therapeutic use)