Abstract | OBJECTIVE: METHODS: We used pharmacological and genetic approaches in mice to study the role of ARs in the antiallodynic action of the TCA nortriptyline. Peripheral neuropathy was induced by the insertion of a polyethylene cuff around the main branch of the sciatic nerve. The specific role of beta(2)-AR was evaluated by studying beta(2)-AR(-/-) mice. We used von Frey filaments to assess mechanical allodynia. RESULTS: INTERPRETATION:
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Authors | Ipek Yalcin, Nada Choucair-Jaafar, Malika Benbouzid, Luc-Henri Tessier, André Muller, Lutz Hein, Marie-José Freund-Mercier, Michel Barrot |
Journal | Annals of neurology
(Ann Neurol)
Vol. 65
Issue 2
Pg. 218-25
(Feb 2009)
ISSN: 1531-8249 [Electronic] United States |
PMID | 19259968
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic Uptake Inhibitors
- Adrenergic alpha-Antagonists
- Adrenergic beta-2 Receptor Antagonists
- Adrenergic beta-Antagonists
- Antidepressive Agents, Tricyclic
- Receptors, Adrenergic, beta-2
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Topics |
- Adrenergic Uptake Inhibitors
(therapeutic use)
- Adrenergic alpha-Antagonists
(therapeutic use)
- Adrenergic beta-2 Receptor Antagonists
- Adrenergic beta-Antagonists
(therapeutic use)
- Animals
- Antidepressive Agents, Tricyclic
(therapeutic use)
- Disease Models, Animal
- Hyperalgesia
(drug therapy, etiology, genetics)
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Motor Activity
(drug effects)
- Pain Measurement
- Receptors, Adrenergic, beta-2
(deficiency, physiology)
- Sciatica
(complications, drug therapy, genetics)
- Time Factors
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