Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population.

Abstract

OBJECTIVE:

Hepatocyte nuclear factor 1beta (HNF1beta) is a transcription factor that is critical for pancreatic cell formation and glucose homeostasis. Previous studies have reported that common variants of HNF1beta were associated with type 2 diabetes in Caucasians and West Africans. However, analysis in the subjects from the Botnia study and Malmö Preventive Project produced conflicting results, and the role for HNF1beta in type 2 diabetes susceptibility remains unclear. We therefore investigated common variants across the HNF1beta gene in a Chinese population.

RESEARCH DESIGN AND METHODS:

Fifteen tagging single nucleotide polymorphisms (SNPs) were analyzed for association with type 2 diabetes in subjects with type 2 diabetes (n = 1,859) and normal glucose regulation (n = 1,785).

RESULTS:

Consistent with the initial study, we observed evidence that the risk G allele of rs4430796 in intron 2 was significantly associated with type 2 diabetes (odds ratio 1.16 [95% CI 1.05-1.29], P = 0.0035, empirical P = 0.0475). Furthermore, the at-risk G allele was associated with earlier age at diagnosis in the type 2 diabetic subjects (P = 0.0228).

CONCLUSIONS:

The result of this study provides evidence that variants in the HNF1beta region contribute to susceptibility to type 2 diabetes in the Chinese population.

• Authors: Congrong Wang, Cheng Hu, Rong Zhang, Yuqian Bao, Xiaojing Ma, Jingyi Lu, Wen Qin, Xinyu Shao, Junxi Lu, Jing Xu, Huijuan Lu, Kunsan Xiang, Weiping Jia
• Journal: Diabetes (Diabetes) Vol. 58 Issue 4 Pg. 1023-7 (Apr 2009) ISSN: 1939-327X [Electronic] United States
• PMID: 19168595 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Hepatocyte Nuclear Factor 1-beta

Topics

• Age of Onset
• Aged
• Asian People (genetics)
• Black People (genetics)
• Blood Glucose
• China
• Diabetes Mellitus, Type 2 (genetics)
• Female
• Genetic Predisposition to Disease
• Genetic Variation
• Hepatocyte Nuclear Factor 1-beta (genetics)
• Humans
• Linkage Disequilibrium
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• White People (genetics)