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Expression and clinical implication of HIF-1alpha and VEGF-C in non-small cell lung cancer.

Abstract
To study the expression and implication of HIF-1alpha and VEGF-C in non-small cell lung cancer (NSCLC) and its relationship with clinical pathological features of NSCLC, immunohistochemical SP was used to detect the expression of HIF-1alpha and VEGF-C proteins in 48 NSCLC tissues and the same para-cancerous tissues. The positive rates of HIF-1alpha and VEGF-C were 70.8% (34/48) and 68.8% (33/48) respectively. The expression of HIF-1alpha protein was detected in a significantly greater proportion in NSCLC carcinoma tissues than that in para-cancerous tissues (12.5% and 16.7%, P<0.05). The positive rates of HIF-1alpha and VEGF-C were correlated with lymph node metastasis and TNM stage. No relationship was found between the two factors and age, sex, pathological subtypes and histological grades. The positive rates between HIF-1alpha and VEGF-C were correlated (P<0.05). HIF-1alpha and VEGF-C were over-expressed in NSCLC. They may be involved in the carcinogenesis of NSCLC, and play an important role in invasion and metastasis of NSCLC. HIF-1alpha and VEGF-C work synergically in the process of NSCLC.
AuthorsShunqing Zuo, Yanmei Ji, Jianjun Wang, Jialong Guo
JournalJournal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban (J Huazhong Univ Sci Technolog Med Sci) Vol. 28 Issue 6 Pg. 674-6 (Dec 2008) ISSN: 1672-0733 [Print] China
PMID19107364 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Vascular Endothelial Growth Factor C
Topics
  • Carcinoma, Non-Small-Cell Lung (metabolism, pathology)
  • Female
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit (metabolism)
  • Lung Neoplasms (metabolism, pathology)
  • Lymphatic Metastasis (pathology)
  • Male
  • Middle Aged
  • Vascular Endothelial Growth Factor C (metabolism)

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