Abstract |
To study the expression and implication of HIF-1alpha and VEGF-C in non-small cell lung cancer (NSCLC) and its relationship with clinical pathological features of NSCLC, immunohistochemical SP was used to detect the expression of HIF-1alpha and VEGF-C proteins in 48 NSCLC tissues and the same para-cancerous tissues. The positive rates of HIF-1alpha and VEGF-C were 70.8% (34/48) and 68.8% (33/48) respectively. The expression of HIF-1alpha protein was detected in a significantly greater proportion in NSCLC carcinoma tissues than that in para-cancerous tissues (12.5% and 16.7%, P<0.05). The positive rates of HIF-1alpha and VEGF-C were correlated with lymph node metastasis and TNM stage. No relationship was found between the two factors and age, sex, pathological subtypes and histological grades. The positive rates between HIF-1alpha and VEGF-C were correlated (P<0.05). HIF-1alpha and VEGF-C were over-expressed in NSCLC. They may be involved in the carcinogenesis of NSCLC, and play an important role in invasion and metastasis of NSCLC. HIF-1alpha and VEGF-C work synergically in the process of NSCLC.
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Authors | Shunqing Zuo, Yanmei Ji, Jianjun Wang, Jialong Guo |
Journal | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
(J Huazhong Univ Sci Technolog Med Sci)
Vol. 28
Issue 6
Pg. 674-6
(Dec 2008)
ISSN: 1672-0733 [Print] China |
PMID | 19107364
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hypoxia-Inducible Factor 1, alpha Subunit
- Vascular Endothelial Growth Factor C
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Topics |
- Carcinoma, Non-Small-Cell Lung
(metabolism, pathology)
- Female
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit
(metabolism)
- Lung Neoplasms
(metabolism, pathology)
- Lymphatic Metastasis
(pathology)
- Male
- Middle Aged
- Vascular Endothelial Growth Factor C
(metabolism)
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