Disulfiram toxicity and carbon disulfide poisoning.

Abstract

The author compared the neurotoxic effects of disulfiram with those of carbon disulfide, a disulfiram metabolite. The results suggest that carbon disulfide is responsible for the behavioral and neurological side effects of disulfiram. If this is so, then some other toxic effects of carbon disulfide, including parkinsonism, choreoathetosis, and thalamic syndrome may follow the ingestion of more than 5 g of disulfiram by adults, and individuals receiving as little as 125 mg of disulfiram per day may be at a three- to four-fold greater risk for arteriosclerotic cardiovascular disease than a comparable population not receiving the drug.

• Authors: J M Rainey Jr
• Journal: The American journal of psychiatry (Am J Psychiatry) Vol. 134 Issue 4 Pg. 371-8 (Apr 1977) ISSN: 0002-953X [Print] United States
• PMID: 190907 (Publication Type: Journal Article)

Chemical References

• Diethylamines
• Ditiocarb
• Carbon Disulfide
• Disulfiram

Topics

• Animals
• Carbon Disulfide (poisoning, toxicity)
• Cardiovascular Diseases (chemically induced)
• Diethylamines (toxicity)
• Disulfiram (toxicity)
• Ditiocarb (toxicity)
• Dyskinesia, Drug-Induced (etiology)
• Environmental Exposure
• Gastrointestinal Diseases (chemically induced)
• Humans
• Occupational Diseases (chemically induced)
• Psychoses, Substance-Induced (etiology)
• Rabbits
• Rats
• Risk