Hyaluronan-mediated motility receptor gene single nucleotide polymorphisms and risk of breast cancer.

Abstract

A recent study used a network modeling strategy to generate a set of genes linked by potential functional associations. The hyaluronan-mediated motility receptor (HMMR) gene was identified as being as functionally associated with BRCA1 and thus a candidate breast cancer gene. SNPs rs10515860, rs299290, and rs7712023 were reported to be significantly associated with breast cancer in a joint analysis of two small case-control studies. We have examined the association of these single nucleotide polymorphisms, together with others tagging the HMMR gene, in a larger, European case-control study and find no association of any of them with risk of breast cancer: rs10515860 [odds ratio (OR; AA/GG), 0.85; 95% confidence interval (CI), 0.65-1.12; P(trend) = 0.9], rs299290 [OR (CC/TT), 1.00; 95% CI, 0.87-1.15; P(trend) = 0.7], rs3756648 (rs7712023) [OR (TT/CC), 0.93; 95% CI, 0.84-1.02; P(trend) = 0.1], rs299284 [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; P(trend) = 0.5], and rs13183712 [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; P(trend) = 0.6].

• Authors: Bolot Kalmyrzaev, Paul D P Pharoah, Douglas F Easton, Bruce A J Ponder, Alison M Dunning, SEARCH Team
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 17 Issue 12 Pg. 3618-20 (Dec 2008) ISSN: 1055-9965 [Print] United States
• PMID: 19064580 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Extracellular Matrix Proteins
• Hyaluronan Receptors
• hyaluronan-mediated motility receptor

Topics

• Breast Neoplasms (genetics)
• Case-Control Studies
• Chi-Square Distribution
• England
• Extracellular Matrix Proteins (genetics)
• False Positive Reactions
• Female
• Genotype
• Humans
• Hyaluronan Receptors (genetics)
• Polymorphism, Single Nucleotide
• Risk