Evaluation of a synthetic wound dressing capable of releasing silver sulfadiazine.

Abstract

A silver sulfadiazine-impregnated poly-L-leucine wound dressing, AgSD-medicated wound dressing, was evaluated for antibacterial capacity against Pseudomonas aeruginosa and cytotoxicity to human fibroblasts and human epidermal keratinocytes. This wound dressing contained 0.4 mg AgSD/cm2. Antibacterial capacity was examined on experimentally infected wound surfaces (3.4 x 10(4) P. aeruginosa organisms/gm) on the dorsum of mice. The AgSD-medicated wound dressing showed effective bacterial control. Cytotoxicity was examined on a monolayer of cells formed in culture dishes. Cellular damage was reduced by the controlled release of AgSD from the hydrophobic poly-L-leucine sponge matrix of the AgSD-medicated wound dressing. Cytotoxicity of the AgSD-medicated wound dressing was much lower than that of 1% AgSD cream.

• Authors: Y Kuroyanagi, E Kim, N Shioya
• Journal: The Journal of burn care & rehabilitation (J Burn Care Rehabil) 1991 Mar-Apr Vol. 12 Issue 2 Pg. 106-15 ISSN: 0273-8481 [Print] United States
• PMID: 1904876 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Biobrane
• Biocompatible Materials
• Coated Materials, Biocompatible
• Delayed-Action Preparations
• Silver Sulfadiazine

Topics

• Animals
• Bacterial Infections (prevention & control)
• Biocompatible Materials (therapeutic use)
• Burns (complications)
• Cell Count (drug effects)
• Cells, Cultured
• Coated Materials, Biocompatible
• Delayed-Action Preparations
• Fibroblasts (drug effects)
• Humans
• Mice
• Occlusive Dressings
• Pseudomonas aeruginosa (drug effects)
• Silver Sulfadiazine (toxicity)
• Skin (cytology)