Evaluation of magnetic resonance signal modification induced by hyaluronic acid therapy in chondromalacia patellae: a preliminary study.

Abstract

Hyaluronic Acid (HA) is an alternative method for the treatment of osteoarthritis (OA), which acts on pain through a double action: anti-inflammatory and synovial fluid (SF) visco-supplementation. Magnetic Resonance Imaging (MRI), utilizing specific sequences, is a valid method for studying the initial phase of chondral damage. The analysis of the data, obtained through the intensity of values taken by positioning Region of Interest (ROIs) within the lesion, determining the differences before and after treatment with HA injected into the knee. The results obtained after six months and one year from the injection were statistically different in respect to those taken before, immediately and after three months of treatment. MRI represents a valid tool to evaluate the grade of chondromalacia patellae and also to follow the cartilage modification induced by HA therapy.

• Authors: N Magarelli, D Palmieri, L Ottaviano, M Savastano, M Barbato, A Leone, A Maggialetti, F P Ciampa, L Bonomo
• Journal: Journal of biological regulators and homeostatic agents (J Biol Regul Homeost Agents) 2008 Oct-Dec Vol. 22 Issue 4 Pg. 247-52 ISSN: 0393-974X [Print] Italy
• PMID: 19036227 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Viscosupplements
• Hyaluronic Acid

Topics

• Adolescent
• Adult
• Chondromalacia Patellae (drug therapy, pathology, physiopathology)
• Female
• Humans
• Hyaluronic Acid (therapeutic use)
• Magnetic Resonance Imaging
• Male
• Quality of Life
• Time Factors
• Viscosupplements (therapeutic use)
• Young Adult