Alendronate protects premenopausal women from bone loss and fracture associated with high-dose glucocorticoid therapy.

Abstract

OBJECTIVE:

We assessed the efficacy of bisphosphonate in premenopausal women (n = 47) commencing high-dose glucocorticoid (GC) therapy in protection against induced bone loss and bone fracture. METHODS. Subjects had just developed systemic autoimmune diseases and were randomized to be treated with 1 mg/kg/day prednisolone and alfacalcidol 1 microg/day alone (alfacalcidol group; n = 22), or prednisolone and alfacalcidol 1 microg/day with alendronate 5 mg/day (alendronate group; n = 25), each for 18 months.

RESULTS:

The percentage changes in lumbar spine bone mineral density (BMD) after 6 months of the therapy were -10.5% +/- 0.8% in the alfacalcidol group, but only -2.1% +/- 1.2% in the combined group. The rate of bone loss in the lumbar spine was significantly lower in the combined group than in the alfacalcidol group at 6 months. At 12 months of treatment, the percentage change in lumbar spine BMD was increased by 1.7% +/- 1.4% in the combined group, but decreased by 9.9% +/- 1.9% in the alfacalcidol group; the difference was significant. Bone fracture occurred at 12 months or later in 4 patients of the alfacalcidol groups, but not in the combined group, even at up to 18 months.

CONCLUSION:

Our results indicate that alendronate with alfacalcidol can maintain BMD and protects against high-dose GC-induced bone loss and bone fracture.

• Authors: Yosuke Okada, Masao Nawata, Shingo Nakayamada, Kazuyoshi Saito, Yoshiya Tanaka
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 35 Issue 11 Pg. 2249-54 (Nov 2008) ISSN: 0315-162X [Print] Canada
• PMID: 19031508 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Bone Density Conservation Agents
• Glucocorticoids
• Hydroxycholecalciferols
• Prednisolone
• alfacalcidol
• Alendronate

Topics

• Adolescent
• Adult
• Alendronate (administration & dosage)
• Autoimmune Diseases (drug therapy)
• Bone Density (drug effects)
• Bone Density Conservation Agents (administration & dosage)
• Drug Therapy, Combination
• Female
• Fractures, Bone (chemically induced, prevention & control)
• Glucocorticoids (administration & dosage, adverse effects)
• Humans
• Hydroxycholecalciferols (administration & dosage)
• Middle Aged
• Osteoporosis (chemically induced, prevention & control)
• Prednisolone (administration & dosage, adverse effects)
• Premenopause
• Young Adult