Abstract |
The ID protein, an inhibitor of basic helix-loop-helix (HLH) transcription factors, has been involved in multiple cellular processes. To investigate the association between tumour advancement and ID expressions of uterine cervical cancers, the levels of ID-1, ID-2 and ID-3 mRNAs were determined by real-time reverse transcription-polymerase chain reaction and the histoscore with the localisation of ID-1 was determined by immunohistochemistry and patient survival in 60 patients. ID-1 histoscores and mRNA levels both significantly (P<0.05) increased in uterine cervical cancers according to clinical stage regardless of histopathological type or lymph node metastasis. Furthermore, the 36-month survival rate of the 30 patients with high ID-1 was poor (60%), whereas that of the other 30 patients with low ID-1 was significantly higher (83%). ID-1 histoscores and mRNA levels significantly (P<0.0001) correlated with microvessel counts in uterine cervical cancers. Tumour cells show mostly diffuse to strong cytoplasmic expression of ID-1 and also very faint expression in endothelial cells. Moreover, ID-1 expression not only correlated with microvessel counts but also correlated significantly with histoscore. Therefore, ID-1 might work on tumour advancement through angiogenic activity and is considered to be a candidate for a prognostic indicator in uterine cervical cancers.
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Authors | M K Maw, J Fujimoto, T Tamaya |
Journal | British journal of cancer
(Br J Cancer)
Vol. 99
Issue 10
Pg. 1557-63
(Nov 18 2008)
ISSN: 1532-1827 [Electronic] England |
PMID | 19002177
(Publication Type: Journal Article)
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Chemical References |
- Angiogenesis Modulating Agents
- Biomarkers, Tumor
- Inhibitor of Differentiation Protein 1
- RNA, Messenger
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Topics |
- Adenocarcinoma
(metabolism)
- Adult
- Aged
- Angiogenesis Modulating Agents
(metabolism)
- Biomarkers, Tumor
(metabolism)
- Carcinoma, Squamous Cell
(metabolism)
- Disease Progression
- Female
- Humans
- Inhibitor of Differentiation Protein 1
(biosynthesis)
- Middle Aged
- Neovascularization, Pathologic
(metabolism)
- Prognosis
- RNA, Messenger
- Survival Analysis
- Uterine Cervical Neoplasms
(metabolism)
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