Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy.

Abstract

A trial to evaluate the safety and immunogenicity of recombinant modified vaccinia Ankara (MVA) and fowlpox (FP) vectors expressing multiple HIV-1 proteins was conducted in twenty HIV-1 infected youth with suppressed viral replication on HAART. The MVA and FP-based multigene HIV-1 vaccines were safe and well tolerated. Increased frequencies of HIV-1 specific CD4+ proliferative responses and cytokine secreting cells were detected following immunization. Increased frequencies and breadth of HIV-1 specific CD8 T-cell responses were also detected. Plasma HIV-1-specific antibody levels and neutralizing activity were unchanged following vaccination. Poxvirus-based vaccines may merit further study in therapeutic vaccine protocols.

• Authors: Thomas C Greenough, Coleen K Cunningham, Petronella Muresan, Margaret McManus, Deborah Persaud, Terry Fenton, Piers Barker, Aditya Gaur, Dennis Panicali, John L Sullivan, Katherine Luzuriaga, Pediatric AIDS Clinical Trials Group P1059 Team
• Journal: Vaccine (Vaccine) Vol. 26 Issue 52 Pg. 6883-93 (Dec 09 2008) ISSN: 0264-410X [Print] Netherlands
• PMID: 18940219 (Publication Type: Clinical Trial, Phase I, Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)

Chemical References

• AIDS Vaccines
• Cytokines
• Gene Products, gag
• HIV Antibodies
• RNA, Viral
• Vaccines, Synthetic
• Interferon-gamma

Topics

• AIDS Vaccines (adverse effects, immunology)
• Adolescent
• Antiretroviral Therapy, Highly Active
• CD4 Lymphocyte Count
• CD4-CD8 Ratio
• Cytokines (biosynthesis)
• Female
• Flow Cytometry
• Fowlpox virus (immunology)
• Gene Products, gag (biosynthesis, genetics)
• HIV Antibodies (analysis, biosynthesis)
• HIV Infections (drug therapy, immunology)
• HIV-1 (genetics, immunology)
• Humans
• Interferon-gamma (biosynthesis)
• Male
• Prospective Studies
• RNA, Viral (analysis, biosynthesis)
• T-Lymphocytes (immunology)
• Vaccines, Synthetic (immunology)
• Vaccinia (immunology)
• Young Adult