Agonist replacement
therapies are effective for managing
substance abuse disorders including
nicotine and
opioid dependence. The results of preclinical laboratory studies and clinical trials indicate that agonist replacements like
D-amphetamine may be a viable option for managing
cocaine dependence. This experiment determined the physiological and behavioral effects of
cocaine during
D-amphetamine maintenance in seven
cocaine-dependent participants. We predicted
cocaine would be well tolerated during
D-amphetamine maintenance. We also predicted
D-amphetamine would attenuate the behavioral effects of
cocaine. After 3-5 days of
D-amphetamine maintenance (0, 15, and 30 mg/day), volunteers were administered ascending doses of
cocaine (4, 30, 60 mg, i.n.) within a single session.
Cocaine doses were separated by 90 min.
Cocaine produced prototypical physiological (e.g., increased heart rate, blood pressure, and body temperature) and subject-rated (e.g., increased ratings of Good Effects) effects. During maintenance on the highest
D-amphetamine dose, the heart rate increasing effects of
cocaine were larger than observed during placebo maintenance. These effects were not clinically significant and no unexpected or serious adverse events were observed.
D-amphetamine attenuated some of the subject-rated effects of
cocaine. These results are concordant with those of previous preclinical studies, human laboratory experiments and clinical trials, further suggesting that agonist replacement
therapy may be a viable strategy for managing
cocaine abuse. Additional research in humans is needed to determine whether
D-amphetamine attenuates the effects of
cocaine under different experimental conditions (e.g., higher
cocaine doses) and behavioral arrangements (e.g.,
drug self-administration or discrimination).