Quantitative PCR assay used to monitor serum Trichosporon asahii DNA concentrations in disseminated trichosporonosis.

Abstract

A bone marrow transplant recipient with disseminated trichosporonosis was successfully treated with voriconazole. Quantitative PCR assay results for Trichosporon asahii DNA in the sera were well correlated with the patient's clinical course. Based on the in vitro susceptibility test, the organism was susceptible to voriconazole.

• Authors: Yoichiro Tsuji, Issei Tokimatsu, Takashi Sugita, Masatoshi Nozaki, Daisuke Kobayashi, Kohsuke Imai, Kazuhiro Kogawa, Shigeaki Nonoyama
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 27 Issue 11 Pg. 1035-7 (Nov 2008) ISSN: 0891-3668 [Print] United States
• PMID: 18845986 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Antigens, Fungal
• DNA, Fungal
• Polysaccharides
• Pyrimidines
• Triazoles
• glucuronoxylomannan
• Voriconazole

Topics

• Adolescent
• Antifungal Agents (pharmacology, therapeutic use)
• Antigens, Fungal (blood)
• Bone Marrow Transplantation
• DNA, Fungal (blood)
• Graft vs Host Disease (complications)
• Humans
• Immunocompromised Host
• Latex Fixation Tests
• Male
• Microbial Sensitivity Tests
• Mycoses (blood, diagnosis, drug therapy, microbiology)
• Polymerase Chain Reaction
• Polysaccharides (blood)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (complications)
• Pyrimidines (therapeutic use)
• Triazoles (therapeutic use)
• Trichosporon (drug effects, genetics, isolation & purification)
• Voriconazole