Abstract |
Despite over 80 years of use, the ketogenic diet (KD) has never been tested in a blinded manner. Twenty children with intractable Lennox-Gastaut syndrome (LGS) were fasted 36 h and then randomized to receive the classic KD in conjunction with a solution containing either 60 g/day of glucose or saccharin. Parents and physicians were blinded to both the solution composition and level of ketosis. A crossover to the KD with the alternate solution occurred following the sixth day and a repeat fast. A 24-h electroencephalography (EEG) was obtained at baseline and after each arm. After administration of the solution, there was moderate evidence of a reduction in parent-reported seizures between the glucose and saccharin arms, with a median difference of 1.5 seizures per day (p = 0.07). There was no reduction in the number of EEG-identified events, with a median reduction of 7 events per day (p = 0.33). Ketosis was not completely eliminated in the glucose-added arm.
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Authors | John M Freeman, Eileen P G Vining, Eric H Kossoff, Paula L Pyzik, Xiaobu Ye, Steven N Goodman |
Journal | Epilepsia
(Epilepsia)
Vol. 50
Issue 2
Pg. 322-5
(Feb 2009)
ISSN: 1528-1167 [Electronic] United States |
PMID | 18717710
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Chemical References |
- Glucose Solution, Hypertonic
- Ketones
- Saccharin
- 3-Hydroxybutyric Acid
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Topics |
- 3-Hydroxybutyric Acid
(urine)
- Child
- Child, Preschool
- Cross-Over Studies
- Diet, Ketogenic
- Double-Blind Method
- Electroencephalography
- Epilepsies, Myoclonic
(diet therapy, urine)
- Epilepsy, Generalized
(diet therapy, urine)
- Female
- Glucose Solution, Hypertonic
(administration & dosage)
- Humans
- Infant
- Ketones
(urine)
- Male
- Saccharin
(administration & dosage)
- Syndrome
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