Abstract | PURPOSE: METHODS: RESULTS: Because of renal insufficiency the patient was treated with systemic prednisone 50 mg/day for 3 weeks. Evolution was favourable, and prednisone was tapered over 10 weeks. Uveitis was treated with topical steroid with good effect. The only complication after 18 months of follow-up was transitory cushingoid aspect. CONCLUSIONS:
Tubulointerstitial nephritis and uveitis syndrome is a rare syndrome that is probably underdiagnosed in clinical practice. Co-operation between ophthalmologists and nephrologists/paediatricians is crucial for early diagnosis and instigation of treatment. Uveitis may occur before tubulointerstitial nephritis or the renal symptoms may be so mild that the patient is unaware of them. Therefore, ophthalmologists play an important role in the initial discovery of patients with TINU syndrome. Tubulointerstitial nephritis tends to be self-limiting, whereas uveitis tends to relapse and recurrences tend to be more severe than the initial uveitis. Therefore, the patient must be ophthalmologically monitored very carefully.
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Authors | Veronica Holm Thomassen, Troels Ring, Jesper Thaarup, Kirsten Baggesen |
Journal | Acta ophthalmologica
(Acta Ophthalmol)
Vol. 87
Issue 6
Pg. 676-9
(Sep 2009)
ISSN: 1755-3768 [Electronic] England |
PMID | 18700885
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
- Anti-Inflammatory Agents
- Dexamethasone
- Prednisone
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Topics |
- Anti-Inflammatory Agents
(adverse effects, therapeutic use)
- Child
- Dexamethasone
(adverse effects, therapeutic use)
- Humans
- Male
- Nephritis, Interstitial
(complications, drug therapy)
- Prednisone
(therapeutic use)
- Renal Insufficiency
(etiology)
- Syndrome
- Treatment Outcome
- Uveitis
(complications)
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