Abstract | OBJECTIVES: METHODS: We analyzed three and four single nucleotide polymorphism (SNP) markers covering VAMP2 and VAMP3, respectively, in an initial BPAD case-control sample of German descent (409 cases, 407 controls). For replication, we analyzed three SNP markers covering VAMP2 in a second sample of the same ethnicity (378 cases, 384 controls). RESULTS: Although no association was found for VAMP3 markers, we observed evidence of association with SNPs at the VAMP2 locus in the initial sample (P values between 0.005 and 0.033). To validate these findings, we analyzed a second BPAD sample and failed to replicate the initial findings at the single-marker and haplotypic level. CONCLUSION: In conclusion, our results do not suggest that a common genetic variant at VAMP2 or VAMP3 contributes to the development of BPAD in German patients.
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Authors | Rami Abou Jamra, Carl Motinda Gobina, Tim Becker, Alexander Georgi, Thomas G Schulze, Christine Schmael, Sven Cichon, Peter Propping, Marcella Rietschel, Markus M Nöthen, Johannes Schumacher |
Journal | Psychiatric genetics
(Psychiatr Genet)
Vol. 18
Issue 4
Pg. 199-203
(Aug 2008)
ISSN: 1473-5873 [Electronic] England |
PMID | 18628682
(Publication Type: Journal Article)
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Chemical References |
- VAMP2 protein, human
- VAMP3 protein, human
- Vesicle-Associated Membrane Protein 2
- Vesicle-Associated Membrane Protein 3
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Topics |
- Adult
- Bipolar Disorder
(genetics)
- Female
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
(genetics)
- Vesicle-Associated Membrane Protein 2
(genetics)
- Vesicle-Associated Membrane Protein 3
(genetics)
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