Metabolism and distribution of guanosine given intraperitoneally: implications for spinal cord injury.

Abstract

Intraperitoneal administration of guanosine to rats with chronic spinal cord injury stimulates remyelination and functional recovery. If guanosine produced its effects in the nervous system, it should enter it and elevate endogenous concentrations. [(3)H]-guanosine (8 mg/kg) was administered intraperitoneally to rats and its distribution and concentration in different sites determined. Guanosine rapidly entered all tissues; its concentration peaked at about 15 minutes except in adipose tissue and CNS where it continued to rise for 30 minutes. Its chief metabolic product in all sites was guanine with over twice as much guanine as guanosine present in CNS after 30 minutes.

• Authors: Shucui Jiang, Gemma Fischione, Patricia Giuliani, Patricia Guiliani, Silvia Romano, Francesco Caciagli, Patrizia Di Iorio, Patrizia Diiorio
• Journal: Nucleosides, nucleotides & nucleic acids (Nucleosides Nucleotides Nucleic Acids) Vol. 27 Issue 6 Pg. 673-80 (Jun 2008) ISSN: 1532-2335 [Electronic] United States
• PMID: 18600525 (Publication Type: Journal Article)

Chemical References

• Guanosine
• Xanthine
• Guanine

Topics

• Animals
• Cell Membrane (metabolism)
• Female
• Guanine (blood, metabolism, pharmacokinetics)
• Guanosine (blood, metabolism, pharmacokinetics, therapeutic use)
• Injections, Intraperitoneal
• Rats
• Spinal Cord Injuries (drug therapy, metabolism)
• Tissue Distribution
• Xanthine (blood, metabolism, pharmacokinetics)