Abstract | BACKGROUND & OBJECTIVE: METHODS: A total of 8434 individuals (7105 AA, 1267 AS and 62 SS) were tested for zinc protoporphyrin/ haem (ZPP/H) ratio and haemoglobin levels. Twenty two sickle cell anaemia (SS), 47 sickle cell trait (AS) and 150 normal control (AA) individuals who were iron deficient, were given iron therapy for a period of 12 wk and the laboratory investigations were repeated at the 13th wk. RESULTS: Sixty seven per cent of subjects with sickle cell anaemia and 26 per cent with sickle cell trait had elevated ZPP/H ratios (>80 micromol/mol) as against 22.8 per cent of normal individuals. The elevated ZPP/H ratios is an indicator of microcytic anaemia of iron deficiency. Following iron therapy, an improvement in the Hb levels and ZPP/H ratios was observed in both sickle cell disorders and normal individual cases. INTERPRETATION & CONCLUSION: This study suggests that iron deficiency anaemia is an important problem in Indian sickle cell anaemia patients and iron supplementation should be given only in proven cases of iron deficiency anaemia.
|
Authors | D Mohanty, M B Mukherjee, R B Colah, M Wadia, K Ghosh, G P Chottray, D Jain, Y Italia, K Ashokan, R Kaul, D K Shukla, V Muthuswamy |
Journal | The Indian journal of medical research
(Indian J Med Res)
Vol. 127
Issue 4
Pg. 366-9
(Apr 2008)
ISSN: 0971-5916 [Print] India |
PMID | 18577791
(Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Protoporphyrins
- zinc protoporphyrin
- Heme
- Iron
|
Topics |
- Adolescent
- Adult
- Anemia, Iron-Deficiency
(blood, drug therapy, epidemiology)
- Anemia, Sickle Cell
(blood, drug therapy, epidemiology)
- Child
- Female
- Heme
(metabolism)
- Humans
- India
(epidemiology)
- Iron
(therapeutic use)
- Iron Deficiencies
- Male
- Prevalence
- Protoporphyrins
(blood)
|