Deferoxamine induces endoplasmic reticulum stress in PC12 cells.

Abstract

Deferoxamine (DFA, N'-[5-(acetyl-hydroxy-amino)-pentyl]-N-[5-[3-(5-aminopentyl-hydroxy-carbamoyl) propanoylamino]pentyl]-N-hydroxy-butane diamide) is a chelating agent used to remove excess iron from the body and to reduce organ and tissue damage. DFA enhances both iron regulatory protein 1 (IRP1) expression and its endoplasmic reticulum (ER) membrane-binding activity, as occurs in hypoxia, an ER stress, in cultured cells. Here, we show that DFA promotes ER stress via an ER signal pathway.

• Authors: Young-Bum Yoo, Kyeong Ryong Lee, Seung-Whan Kim, Kisang Kwon, Tae-Won Goo, O-Yu Kwon
• Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences (Z Naturforsch C J Biosci) 2008 Mar-Apr Vol. 63 Issue 3-4 Pg. 308-10 ISSN: 0939-5075 [Print] Germany
• PMID: 18533479 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA Primers
• Deferoxamine

Topics

• Animals
• Cell Line
• DNA Primers
• Deferoxamine (pharmacology)
• Endoplasmic Reticulum (drug effects, physiology)
• PC12 Cells (drug effects)
• Rats
• Reverse Transcriptase Polymerase Chain Reaction
• Signal Transduction (drug effects, physiology)