In vivo anti-inflammatory and antinociceptive actions of some Lamium species.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Several Lamium species have been used to relieve pain in arthritic ailments in Turkish folk medicine.

AIM OF THE STUDY:

To evaluate the anti-inflammatory and antinociceptive activities of different extracts prepared with methanol, dichloromethane, n-butanol and water from the aerial parts of some Lamium species of Turkish origin.

MATERIALS AND METHODS:

Lamium eriocephalum subsp. eriocephalum, Lamium garganicum subsp. laevigatum, Lamium garganicum subsp. pulchrum and Lamium purpureum var. purpureum (Lamiaceae); for the anti-inflammatory activity, carrageenan-induced hind paw edema model, PGE(2)-induced hind paw edema model, and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema model and for the antinociceptive activity p-benzoquinone (PBQ)-induced writhing test in mice were employed.

RESULTS:

The n-butanol extracts of Lamium garganicum subsp. laevigatum (LGL-BuOH), Lamium garganicum subsp. pulchrum (LGP-BuOH), and Lamium purpureum var. purpureum (LPP-BuOH) exhibited notable inhibition (16.5-28.9, 14.5-26.9, 12.3-21.5%, resp.) in carrageenan-induced hind paw edema model at doses of 200mg/kg without inducing any gastric damage. The LGL-BuOH (7.1-30.4%) and LGP-BuOH (5.9-24.1%) extracts also displayed potent anti-inflammatory activity against PGE(2)-induced hind paw edema model. LGL-BuOH and LGP-BuOH were also found to exhibit remarkable antinociceptive activity in p-benzoquinone-induced abdominal constriction test at a dose of 200 mg/kg (25.0 and 24.3%, respectively).

CONCLUSION:

The experimental data demonstrated that Lamium garganicum subsp. laevigatum and Lamium garganicum subsp. pulchrum displayed remarkable anti-inflammatory and antinociceptive activities.

• Authors: Esra Küpeli Akkol, Funda Nuray Yalçin, Duygu Kaya, Ihsan Caliş, Erdem Yesilada, Tayfun Ersöz
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 118 Issue 1 Pg. 166-72 (Jun 19 2008) ISSN: 0378-8741 [Print] Ireland
• PMID: 18486371 (Publication Type: Journal Article)

Chemical References

• Analgesics
• Anti-Inflammatory Agents
• Plant Extracts

Topics

• Analgesics (administration & dosage, adverse effects, isolation & purification)
• Animals
• Anti-Inflammatory Agents (administration & dosage, adverse effects, isolation & purification)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Inflammation (drug therapy)
• Lamiaceae (chemistry)
• Male
• Medicine, Traditional
• Mice
• Pain (drug therapy)
• Plant Extracts (administration & dosage, adverse effects)
• Turkey