Abstract | BACKGROUND:
Heart disease is a leading cause of mortality throughout the world. Tissue damage from vascular occlusive events results in the replacement of contractile myocardium by nonfunctional scar tissue. The potential of new technologies to regenerate damaged myocardium is significant, although cell-based therapies must overcome several technical barriers. One possible cell-independent alternative is the direct administration of small proteins to damaged myocardium. METHODS AND RESULTS: CONCLUSIONS: These findings suggest that SDF-1alpha may serve a tissue-protective and regenerative role for solid organs suffering a hypoxic insult.
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Authors | Ankur Saxena, Jason E Fish, Michael D White, Sangho Yu, James W P Smyth, Robin M Shaw, J Michael DiMaio, Deepak Srivastava |
Journal | Circulation
(Circulation)
Vol. 117
Issue 17
Pg. 2224-31
(Apr 29 2008)
ISSN: 1524-4539 [Electronic] United States |
PMID | 18427137
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cardiotonic Agents
- Chemokine CXCL12
- Vascular Endothelial Growth Factor A
- vascular endothelial growth factor A, mouse
- Proto-Oncogene Proteins c-akt
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Topics |
- Animals
- Apoptosis
(drug effects)
- Cardiotonic Agents
(pharmacology)
- Chemokine CXCL12
(pharmacology)
- Echocardiography
- Male
- Mice
- Mice, Inbred C57BL
- Myocardial Infarction
(diagnostic imaging, drug therapy, pathology)
- Myocardial Ischemia
(diagnostic imaging, drug therapy, pathology)
- Myocardium
(pathology)
- Neovascularization, Physiologic
(drug effects)
- Phosphorylation
(drug effects)
- Proto-Oncogene Proteins c-akt
(metabolism)
- Regeneration
(drug effects)
- Vascular Endothelial Growth Factor A
(metabolism)
- Ventricular Function, Left
(drug effects)
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