We evaluated the effect of
DHEA complementary treatment in
opiate addicts undergoing detoxification.
DHEA (100 mg/day) or placebo was added to the routine medication protocol in a randomized, double blind controlled study. Follow-up for 12 months was conducted. Two separate
DHEA-treated subgroups were identified by the Fuzzy clustering method: one showed statistically significant improvement in the severity of
withdrawal symptoms, depression and anxiety scores (n=34; p<0.001 for all) and the other subgroup deteriorated in all measures (n=15).
DHEA at the end of the detoxification program showed a tendency towards correlation with the duration of abstinence (r=0.6843; p>0.05; n=6), while a negative correlation was obtained with the
cortisol level (r=-0.900; p=0.005, n=8). The completion-rate of the
DHEA-improved subgroup was greater than in the
DHEA-deteriorated subgroup (64.7% vs. 33.3%, respectively). The influence of supplementary
DHEA treatment was mostly effective in
heroin addicts who had not previously used either
cocaine or
benzodiazepines and who had experienced only few withdrawal programs.