Abstract | BACKGROUND: METHODS: This was a double-blind, randomized, placebo-controlled, crossover trial of d-MPH. Patients were seen weekly and completed Functional Assessment of Chronic Illness Therapy- Fatigue (FACIT-F) and Fatigue Assessment Score (FAS) instruments. After a 1-week wash-in period, patients received either d-MPH or placebo. After 8 weeks, the medications were stopped. Following a 2-week wash-out period, patients were crossed over to 8 weeks of the other treatment. FVC and 6-min walk distance (6MWD) were determined initially and after each treatment arm. RESULTS: Ten patients with sarcoidosis were enrolled: 8 women and 5 African Americans. All were receiving systemic sarcoidosis therapy. Significant improvement in fatigue was reported by patients when receiving d-MPH (FACIT-F, p < 0.001; FAS, p < 0.02). FVC was higher at the end of 8 weeks of d-MPH compared to the baseline values (baseline median, 2.38 L; range, 1.17 to 4.53 L; placebo median, 2.41 L; range, 1.50 to 4.65 L; d-MPH median, 2.56 L; range, 1.50 to 4.96 L; p < 0.01). There was no significant difference in the 6MWD (baseline median, 330 m; range, 60 to 460 m; placebo median, 350 m; range, 180 to 460 m; d-MPH median, 390 m; range, 200 to 460 m). d-MPH was well tolerated. CONCLUSIONS: Treatment with d-MPH was associated with a significant improvement in sarcoidosis-associated fatigue. TRIAL REGISTRATION: Clinicaltrials.gov Identifier: NCT00361387.
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Authors | Elyse E Lower, Stacy Harman, Robert P Baughman |
Journal | Chest
(Chest)
Vol. 133
Issue 5
Pg. 1189-95
(May 2008)
ISSN: 0012-3692 [Print] United States |
PMID | 18263672
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Central Nervous System Stimulants
- Glucocorticoids
- Immunosuppressive Agents
- Dexmethylphenidate Hydrochloride
- Methylphenidate
|
Topics |
- Adult
- Aged
- Central Nervous System Stimulants
(therapeutic use)
- Cross-Over Studies
- Dexmethylphenidate Hydrochloride
- Double-Blind Method
- Drug Therapy, Combination
- Exercise Test
(methods)
- Fatigue
(diagnosis, drug therapy, etiology)
- Female
- Follow-Up Studies
- Glucocorticoids
(therapeutic use)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Male
- Methylphenidate
(therapeutic use)
- Middle Aged
- Respiratory Function Tests
- Retrospective Studies
- Sarcoidosis, Pulmonary
(complications, diagnosis, drug therapy)
- Severity of Illness Index
- Surveys and Questionnaires
- Treatment Outcome
- Walking
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