Abstract |
The effects of interferon (IFN) alpha-2a treatment on platelet function were evaluated in 20 patients affected by essential thrombocythaemia (ET). Baseline data documented the well-known abnormalities of in vitro platelet aggregation and the constant presence of a delta- storage pool deficiency. The therapy in all patients reduced the platelet count, and in the majority of them caused a partial improvement of in vitro platelet aggregation. Although the mean intraplatelet ADP level improved during treatment, it always remained below the normal range documenting persistence of the delta- storage pool deficiency. The plasma beta-TG levels, which initially were high, significantly decreased during treatment, but the beta-TG ratio and the platelet beta-TG values always remained within the normal range--this suggests an absence of platelet activation either before or during therapy. Our results demonstrate that, despite significantly reducing the platelet count, IFN alpha-2a treatment only partially corrects the qualitative platelet abnormalities in ET.
|
Authors | L Catani, L Gugliotta, M L Cascione, M Mattioli Belmonte, N Vianelli, A R Belardinelli, S Tura |
Journal | European journal of haematology
(Eur J Haematol)
Vol. 46
Issue 3
Pg. 158-62
(Mar 1991)
ISSN: 0902-4441 [Print] England |
PMID | 1826272
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Interferon Type I
- beta-Thromboglobulin
- Platelet Factor 4
- Adenosine Diphosphate
- Adenosine Triphosphate
- Collagen
- Epinephrine
|
Topics |
- Adenosine Diphosphate
(analysis, pharmacology)
- Adenosine Triphosphate
(analysis)
- Adolescent
- Adult
- Aged
- Blood Platelets
(chemistry, drug effects)
- Collagen
(pharmacology)
- Epinephrine
(pharmacology)
- Female
- Humans
- Interferon Type I
(pharmacology)
- Male
- Middle Aged
- Platelet Aggregation
(drug effects)
- Platelet Count
(drug effects)
- Platelet Factor 4
(analysis)
- Platelet Storage Pool Deficiency
(drug therapy)
- Thrombocythemia, Essential
(drug therapy)
- beta-Thromboglobulin
(analysis)
|