Urinary cytology and nuclear matrix protein 22 in the detection of bladder cancer recurrence other than transitional cell carcinoma.

Abstract

OBJECTIVE:

To assess the value of nuclear matrix protein-22 (NMP22), compared with urinary cytology, in predicting the recurrence of bladder cancer that is not transitional cell carcinoma (non-TCC).

PATIENTS AND METHODS:

We tested the sensitivity, specificity and the predictive accuracy of NMP22 in the context of non-TCC bladder cancer recurrence, and compared it to the performance of urinary cytology. The study group comprised 2687 patients with history of non-muscle-invasive bladder cancer from 10 centres across four continents.

RESULTS:

The mean patient age was 64.8 years and 75.4% were men; of all patients, 513 (19.1%) had positive urinary cytology, 906 (33.7%) had a positive NMP22 test (>or=10 units/mL) and 80 (3.0%) had non-TCC recurrence. Most of these, i.e. 60 (75%), were stage >or=T2. The sensitivity and specificity of urinary cytology were, respectively, 20.0% and 94.8%, vs 77.5% and 81.8% for NMP22 of >or=10 units/mL. The predictive accuracy of urinary cytology was 57.5%, vs 87.1% for NMP22 >or= 10 units/mL. A combined model that included dichotomized NMP22 and urinary cytology was 85.3% accurate.

CONCLUSION:

The ability of a NMP22 level of >or=10 units/mL to predict non-TCC recurrence was better than that of urinary cytology, suggesting that NMP22 might have a role in the surveillance of patients at risk of non-TCC recurrence.

• Authors: Georg C Hutterer, Pierre I Karakiewicz, Craig Zippe, Gerson Lüdecke, Hans Boman, Marta Sanchez-Carbayo, Roberto Casella, Christine Mian, Martin G Friedrich, Sanaa Eissa, Hideyuki Akaza, Vincenzo Serretta, Hans Hedelin, Raina Rupesh, Naoto Miyanaga, Arthur I Sagalowsky, Paul Perrotte, Yair Lotan, Michael J Marberger, Shahrokh F Shariat
• Journal: BJU international (BJU Int) Vol. 101 Issue 5 Pg. 561-5 (Mar 2008) ISSN: 1464-410X [Electronic] England
• PMID: 18257856 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Nuclear Proteins
• nuclear matrix protein 22

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (metabolism)
• Carcinoma, Squamous Cell (pathology, urine)
• Child
• Cohort Studies
• Female
• Humans
• Male
• Middle Aged
• Neoplasm Recurrence, Local (diagnosis, urine)
• Nuclear Proteins (metabolism)
• Predictive Value of Tests
• Prognosis
• Retrospective Studies
• Risk Factors
• Sensitivity and Specificity
• Urinary Bladder Neoplasms (diagnosis, pathology, urine)