Abstract | BACKGROUND/AIMS:
Polyamines are essential to survival, growth, and proliferation of mammalian cells. Previous studies have suggested that the pancreatic polyamine levels may change in acute pancreatitis. In this study, the changes of polyamine levels in the pancreas have been studied with respect to the severity of pancreatitis. We investigated whether there is a relationship in polyamine levels between pancreas and blood, and whether pancreatic and blood polyamine levels change according to the severity of pancreatitis. METHODS: RESULTS: Infusion of 6% taurodeoxycholate as compared with 2% resulted in more severe pancreatitis, as revealed by mortality, histology, and serum amylase activity. Pancreatic spermidine/spermine N(1)-acetyltransferase was induced early after pancreatitis and was associated with increased putrescine and decreased spermidine levels. The extent of pancreatic necrosis significantly correlated with the polyamine catabolism indicators pancreatic putrescine/ spermidine ratio (r = 0.29, p < 0.01) and pancreatic putrescine/ spermine ratio (r = 0.32, p < 0.01). The two pancreatic polyamine ratios correlated well also with the red blood cell polyamine ratios (r = 0.75 and r = 0.72, respectively, both p < 0.01). Furthermore, the extent of pancreatic necrosis correlated with red blood cell putrescine/ spermidine (r = 0.32, p < 0.01) and putrescine/ spermine (r = 0.37, p < 0.01) ratios. CONCLUSIONS:
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Authors | Hai-Tao Jin, Teemu Lamsa, Mari Merentie, Mervi T Hyvonen, Juhani Sand, Sari Raty, Karl-Heinz Herzig, Leena Alhonen, Isto Nordback |
Journal | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
(Pancreatology)
Vol. 8
Issue 1
Pg. 15-24
( 2008)
ISSN: 1424-3911 [Electronic] Switzerland |
PMID | 18235212
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2008 S. Karger AG, Basel. |
Chemical References |
- Polyamines
- Taurodeoxycholic Acid
- Amylases
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Topics |
- Amylases
(blood, metabolism)
- Animals
- Dose-Response Relationship, Drug
- Male
- Pancreas
(metabolism)
- Pancreatitis
(blood, chemically induced)
- Polyamines
(blood, metabolism)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Taurodeoxycholic Acid
(toxicity)
- Time Factors
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