[The value of the level of alpha-1,4-glucosidase and seminal l-carnitine in patients with oligoasthenospermia].

Abstract

Samples of sperm have been obtained from 95 who consulted us for infertility. In each case seminal plasma was examined for levels of alpha-1,4-glucosidase and L-carnitine. Our results have led us to fix the threshold value of 42.6 mlU per ejaculate for alpha-1,4-glucosidase and 960 nanomoles of L-carnitine below those levels that we thought occur where the origin of the oligospermia is obstructive (series 1 patients). In series 2 patients the cause of the oligospermia purely being secretory, there is normal epididymal function and therefore the excretory doubts are proven. It is not impossible to have both pathologies because we have found this in men of the intermediate groups C and D. We have found that there is a correlation between the presence of epididymal pathology and a drop in epididymal markers which can be found in severe oligospermia (which can be epididymal in origin and not testicular). Also when there is non abnormalities in the spermogram. This last situation can occur in "invisible" abnormalities of spermaturation in the epidymus.

• Authors: H Ben Ali, J F Guérin, C Bouzakoura, J C Czyba
• Journal: Journal de gynecologie, obstetrique et biologie de la reproduction (J Gynecol Obstet Biol Reprod (Paris)) Vol. 20 Issue 6 Pg. 783-9 ( 1991) ISSN: 0368-2315 [Print] France
• Vernacular Title: Intérêt du dosage de l'alpha-1,4-glucosidase et de la L-carnitine séminales chez des sujets oligoasthénospermiques.
• PMID: 1822486 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers
• alpha-Glucosidases
• Carnitine

Topics

• Biomarkers (chemistry)
• Carnitine (analysis)
• Epididymis (chemistry, pathology)
• Humans
• Male
• Oligospermia (metabolism, pathology)
• Semen (chemistry, enzymology)
• Sperm Count
• Sperm Motility
• Testicular Diseases (metabolism, pathology)
• alpha-Glucosidases (analysis)