Therapeutic approach of histamine H3 receptors in obesity.

Abstract	Obesity is considered one of the risk factors for metabolic disorders. There is increasing evidence that obesity is under control of several cytokines and hormone in the brain. Brain histamine and H3 receptors are important factors for regulating obesity. The results of physiological and pharmacological studies revealed that brain histamine and H3 receptors are involved in the regulation of obesity. In this review, we describe the implication and patent for developing H3 receptor antagonists and their therapeutic potential of obesity.
Authors	Takayuki Masaki, Hironobu Yoshimatsu
Journal	Recent patents on CNS drug discovery (Recent Pat CNS Drug Discov) Vol. 2 Issue 3 Pg. 238-40 (Nov 2007) ISSN: 1574-8898 [Print] United Arab Emirates
PMID	18221234 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References	Histamine Antagonists Receptors, Histamine H3 Histamine
Topics	Animals Histamine (metabolism) Histamine Antagonists (chemistry, therapeutic use) Humans Obesity (drug therapy, metabolism) Receptors, Histamine H3 (physiology)

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