Dipeptide preparation Noopept prevents scopolamine-induced deficit of spatial memory in BALB/c mice.

Abstract

The effect of original nootropic preparation Noopept on learning and long-term memory was studied with BALB/c mice. Scopolamine (1 mg/kg) impaired long-term memory trace, while Noopept (0.5 mg/kg) had no significant effect. Noopept completely prevented the development of cognitive disorders induced by scopolamine (blockade of muscarinic cholinergic receptors). Our results confirmed the presence of choline-positive effect in dipeptide piracetam analogue Noopept on retrieval of learned skill of finding a submerged platform (spatial memory). We conclude that the effectiveness of this drug should be evaluated in patients with Alzheimer's disease.

• Authors: A P Belnik, R U Ostrovskaya, I I Poletaeva
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 143 Issue 4 Pg. 431-3 (Apr 2007) ISSN: 0007-4888 [Print] United States
• PMID: 18214292 (Publication Type: Journal Article)

Chemical References

• Dipeptides
• Neuroprotective Agents
• Nootropic Agents
• ethyl phenylacetyl-Pro-Gly
• Scopolamine

Topics

• Animals
• Dipeptides (pharmacology)
• Male
• Maze Learning (drug effects)
• Memory (drug effects)
• Mice
• Mice, Inbred BALB C
• Neuroprotective Agents (pharmacology)
• Nootropic Agents (pharmacology)
• Scopolamine (pharmacology)
• Space Perception (drug effects)