Abstract | INTRODUCTION: Delayed ischemic neurological deficit associated to cerebral vasospasm is the most common cause of sequelae and death that follows the rupture of an aneurysm. The objective of this study was to evaluate the safety and efficacy of intra-arterial Milrinone in patients with symptomatic refractory cerebral vasospasm. PATIENTS AND METHOD: RESULTS: All patients had a significant angiographic response. This was evidenced by a pre-treatment vessel stenosis greater than 70%, that improved to less than 50% after the intra-arterial Milrinone infusion. Three patients developed recurrent vasospasm that improved after a second intra-arterial Milrinone infusion. None of the patients developed neurologic or systemic complications attributed to the intervention. At 3 months follow-up all patients were alive and had a mean modified Rankin scale of 2 +/- 1 and a Barthel index of 83 +/- 10. CONCLUSION:
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Authors | C M Romero, D Morales, A Reccius, F Mena, J Prieto, P Bustos, J Larrondo, J Castro |
Journal | Neurocritical care
(Neurocrit Care)
Vol. 11
Issue 2
Pg. 165-71
( 2009)
ISSN: 1541-6933 [Print] United States |
PMID | 18202923
(Publication Type: Journal Article)
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Chemical References |
- Platelet Aggregation Inhibitors
- Milrinone
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Topics |
- Adult
- Blood Pressure
- Carotid Stenosis
(diagnostic imaging, drug therapy)
- Cerebral Angiography
- Female
- Heart Rate
- Humans
- Infusions, Intra-Arterial
- Intracranial Aneurysm
(drug therapy)
- Intracranial Pressure
(drug effects, physiology)
- Middle Aged
- Milrinone
(administration & dosage, therapeutic use)
- Platelet Aggregation Inhibitors
(administration & dosage, therapeutic use)
- Prospective Studies
- Safety
- Vasospasm, Intracranial
(diagnostic imaging, drug therapy, physiopathology)
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