Efficacy of once-daily olopatadine 0.2% ophthalmic solution compared to twice-daily olopatadine 0.1% ophthalmic solution for the treatment of ocular itching induced by conjunctival allergen challenge.

Abstract

Olopatadine 0.1% (Patanol) and olopatadine 0.2% (Pataday) ophthalmic solutions are topical ocular anti-allergic agents with antihistaminic and mast cell stabilizing properties. The efficacy of two doses of olopatadine 0.1% was compared to one dose of olopatadine 0.2% in the prevention of ocular itching associated with allergic conjunctivitis over 24 hours. This double-masked conjunctival allergen challenge (CAC) study found no significant difference in the mean itching scores between two drops of olopatadine 0.1% and one drop of olopatadine 0.2%. Both showed significant activity at the 24-hour time point and were statistically superior to placebo. No adverse events occurred while on drug therapy.

• Authors: Mark B Abelson, Dennis L Spangler, Arthur B Epstein, Francis S Mah, H Jerome Crampton
• Journal: Current eye research (Curr Eye Res) Vol. 32 Issue 12 Pg. 1017-22 (Dec 2007) ISSN: 0271-3683 [Print] England
• PMID: 18085465 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Allergens
• Dibenzoxepins
• Histamine H1 Antagonists, Non-Sedating
• Ophthalmic Solutions
• Olopatadine Hydrochloride

Topics

• Adult
• Allergens (adverse effects)
• Conjunctiva (drug effects)
• Conjunctivitis, Allergic (chemically induced, drug therapy)
• Dibenzoxepins (administration & dosage)
• Double-Blind Method
• Female
• Histamine H1 Antagonists, Non-Sedating (administration & dosage)
• Humans
• Male
• Olopatadine Hydrochloride
• Ophthalmic Solutions (administration & dosage)
• Pruritus (drug therapy)
• Skin Tests
• Treatment Outcome