Angiogenic and cell proliferating action of the natural diarylnonanoids, malabaricone B and malabaricone C during healing of indomethacin-induced gastric ulceration.

Abstract

PURPOSE:

To evaluate the plant phenolics, malabaricone B (mal B) and malabaricone C (mal C) in healing stomach ulcer by modulating angiogenesis.

MATERIALS AND METHODS:

Male Swiss albino mice, ulcerated with indomethacin (18 mg/kg, p. o., single dose) were treated up to 7 days with different doses of mal B or mal C. The healing capacities of the drugs and their effects on the angiogenic parameters were assessed.

RESULTS:

Maximum ulceration, observed on the 3rd day after indomethacin administration was effectively healed by mal B and mal C (each 10 mg/kg, p. o. x 3 days), the latter showing equivalent potency (~78% p < 0.001) as that of Omez (3 mg/kg, p. o. x 3 days) and misoprostol (10 mug/kg, p. o. x 3 days). Compared to the untreated mice, those treated with mal B or mal C respectively for 3 days increased the mucosal EGF level (139 and 178%, p < 0.001), the serum VEGF level (56%, p < 0.01 and 95%, p < 0.001) and microvessels formation (37%, p < 0.05 and 62%, p < 0.01), while reducing the serum endostatin level (37%, p < 0.05 and 61%, p < 0.01). The relative healing capacities of mal B and mal C correlated well with their respective abilities to modulate the angiogenic factors. The healing by Omez and misoprostol was not due to improved angiogenesis.

CONCLUSIONS:

The drugs, mal B and mal C could effectively heal indomethacin-induced stomach ulceration in mice by promoting angiogenesis.

• Authors: Debashish Banerjee, Biswanath Maity, Atmaram H Bandivdeker, Sandip K Bandyopadhyay, Subrata Chattopadhyay
• Journal: Pharmaceutical research (Pharm Res) Vol. 25 Issue 7 Pg. 1601-9 (Jul 2008) ISSN: 0724-8741 [Print] United States
• PMID: 18071876 (Publication Type: Journal Article)

Chemical References

• Angiogenesis Inhibitors
• Anti-Inflammatory Agents, Non-Steroidal
• Anti-Ulcer Agents
• Endostatins
• Resorcinols
• Vascular Endothelial Growth Factor A
• von Willebrand Factor
• Misoprostol
• Epidermal Growth Factor
• malabaricone B
• malabaricone C
• Omeprazole
• Indomethacin

Topics

• Angiogenesis Inhibitors (metabolism)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal
• Anti-Ulcer Agents (pharmacology)
• Cell Proliferation (drug effects)
• Dose-Response Relationship, Drug
• Endostatins (metabolism)
• Epidermal Growth Factor (biosynthesis, metabolism)
• Gastric Mucosa (blood supply, drug effects)
• Granulation Tissue (drug effects)
• Indomethacin
• Male
• Mice
• Misoprostol (pharmacology)
• Neovascularization, Physiologic (drug effects)
• Omeprazole (pharmacology)
• Regional Blood Flow (drug effects)
• Resorcinols (pharmacology)
• Stomach Ulcer (chemically induced, drug therapy, pathology)
• Vascular Endothelial Growth Factor A (metabolism)
• von Willebrand Factor (metabolism)