Abstract | BACKGROUND: METHODS: Relevant English-language publications were identified through a search of the PubMed database (1980-2007). Search terms included diabetes, in combination with subcutaneous and/or inhaled insulin. A similar search of abstracts from the 2006 American Diabetes Association 66th Annual Scientific Sessions was also performed. RESULTS: Eight clinical studies to date have reported that IDPI consistently improved glycemic control, whether used in combination with longer-acting SC insulin regimens in patients with type 1 or type 2 DM or to supplement or replace oral agent therapy in patients with type 2 DM. Evidence to date suggests that IDPI is associated with an acceptable tolerability profile, with a risk of hypoglycemia similar to that of SC insulin (risk ratios in 2 studies were 0.94 and 0.96, in favor of IDPI). Moreover, no clinically significant changes in pulmonary function have been noted. Patients treated with IDPI in clinical studies reported significantly greater improvements in overall satisfaction with treatment compared with SC insulin (P < 0.01) or oral agent therapy (P = 0.02). CONCLUSION: IDPI is effective and well tolerated for the treatment of diabetes and may be an option for patients to achieve glycemic control.
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Authors | George Dailey |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 29 Spec No
Pg. 1271-83
( 2007)
ISSN: 0149-2918 [Print] United States |
PMID | 18046927
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Insulin
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Topics |
- Diabetes Mellitus, Type 1
(blood, drug therapy)
- Diabetes Mellitus, Type 2
(blood, drug therapy)
- Drug Delivery Systems
(instrumentation, methods)
- Glycated Hemoglobin
(metabolism)
- Humans
- Hypoglycemic Agents
(administration & dosage, pharmacokinetics, therapeutic use)
- Insulin
(administration & dosage, pharmacokinetics, therapeutic use)
- Lung
(metabolism)
- Randomized Controlled Trials as Topic
- Treatment Outcome
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