Translation in vitro of vesicular stomatitis virus mRNA lacking 5'-terminal 7-methylguanosine.

Abstract

The 5'-terminus 7-methylguanosine of vesicular stomatitis virus mRNA is not essential for translation of the mRNA. The 7-methylguanosine seems to have a mediating rather than an obligatory role in ribosome binding by the mRNA and in mRNA translation.

• Authors: J K Rose, H F Lodish
• Journal: Nature (Nature) Vol. 262 Issue 5563 Pg. 32-7 (Jul 01 1976) ISSN: 0028-0836 [Print] England
• PMID: 180425 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Guanine Nucleotides
• RNA, Messenger
• RNA, Viral

Topics

• Cell-Free System
• Guanine Nucleotides (metabolism)
• Kinetics
• Peptide Chain Initiation, Translational
• Protein Biosynthesis
• RNA, Messenger (metabolism)
• RNA, Viral (metabolism)
• Ribosomes (metabolism)
• Structure-Activity Relationship
• Vesicular stomatitis Indiana virus (metabolism)