Outcome of haematopoietic stem cell transplantation for paediatric acute lymphoblastic leukaemia in third complete remission: a vital role for graft-versus-host-disease/ graft-versus-leukaemia effect in survival.

Abstract

Children with acute lymphoblastic leukaemia (ALL) receiving haematopoietic stem cell transplantation (HSCT) in third complete remission (CR3) are at high risk for transplant-related mortality (TRM) and relapse. Twenty-two consecutive children with ALL in CR3 received HSCT between January 1994 and August 2005. Ten patients died of TRM, seven patients relapsed, six did not have graft-versus-host disease (GVHD). Five patients were long-term survivors, (median follow-up, 5.8 years; range 2.9-11.7). Three-year event-free survival was 0.32 (95% confidence interval 0.19 and 0.59). Survivors had moderate to severe GVHD. Allowing some GVHD or exploring means of inducing GVHD should be considered in CR3 patients.

• Authors: Adam Gassas, M Kashif Ishaqi, Samina Afzal, Annie Dupuis, John Doyle
• Journal: British journal of haematology (Br J Haematol) Vol. 140 Issue 1 Pg. 86-9 (Jan 2008) ISSN: 1365-2141 [Electronic] England
• PMID: 17894841 (Publication Type: Journal Article)

Topics

• Adolescent
• Child
• Child, Preschool
• Disease-Free Survival
• Female
• Graft vs Host Disease (mortality)
• Graft vs Leukemia Effect
• Hematopoietic Stem Cell Transplantation (methods, mortality)
• Humans
• Male
• Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (mortality, therapy)
• Remission Induction