[Diabetic nephropathy: glomerular filtration rate and estimated creatinine clearance].

Abstract

OBJECTIVE:

To assess in diabetic nephropathy, the accuracy of estimated creatinine clearance (calculated with the Cockroft Gault formula) and the clearance of the Tc99m-DTPA, to measure the glomerular filtration rate (GFR).

PATIENTS AND METHODS:

We analysed the GFR measure by Tc99m-DTPA method and the estimated by the Cockroft Gault formula, in 21 subjects with type 1 or type 2 diabetes.

RESULTS:

There was a strong positive correlation between the two methods but the Cockroft Gault formula underestimated the GFR.

CONCLUSIONS:

The formula gives a accurate estimates of GFR, when GFR is <100 ml/min/1,73 m2. Beside the underestimation, the formula could be used in the management of diabetic nephropathy because the repeated isotope assessments of renal function are impracticable.

• Authors: Joana Guimarães, Margarida Bastos, Miguel Melo, Manuela Carvalheiro
• Journal: Acta medica portuguesa (Acta Med Port) 2007 Mar-Apr Vol. 20 Issue 2 Pg. 145-50 ISSN: 1646-0758 [Electronic] Portugal
• Vernacular Title: Nefropatia diabética: taxa de filtração glomerular calculada e estimada.
• PMID: 17868520 (Publication Type: English Abstract, Journal Article)

Chemical References

• Creatinine

Topics

• Creatinine (metabolism)
• Diabetes Mellitus, Type 1 (metabolism, physiopathology)
• Diabetes Mellitus, Type 2 (metabolism, physiopathology)
• Diabetic Nephropathies (metabolism, physiopathology)
• Female
• Glomerular Filtration Rate
• Humans
• Male
• Middle Aged
• Retrospective Studies