Endocrine cells in a normal breast and non-cancerous breast lesion.

Abstract

The authors confirmed the presence of endocrine cells for the first time in a normal breast as well as in a non-cancerous lesion of the breast. One hundred and eighty-eight blocks of normal breast tissues in 44 cases and 74 blocks of non-cancerous lesions in 35 cases were examined. Argyrophil cells were found in one block from a normal breast and in one block from a phyllodes tumor. Argyrophil cells in the normal breast showed positive reaction to anti-endocrine granule constituent (EGC) antibody with immunohistochemical method. Argyrophil cells found in the phyllodes tumor gave positive reaction to both anti-EGC and anti-serotonin antibodies. The present study is thought to be the first report in the literature of serotonin-positive cells in a non-cancerous breast lesion, a phyllodes tumor.

• Authors: T Satake, M Matsuyama
• Journal: Acta pathologica japonica (Acta Pathol Jpn) Vol. 41 Issue 12 Pg. 874-8 (Dec 1991) ISSN: 0001-6632 [Print] Australia
• PMID: 1785346 (Publication Type: Journal Article)

Chemical References

• Serotonin

Topics

• Adult
• Aged
• Aged, 80 and over
• Breast (chemistry, cytology, pathology, ultrastructure)
• Breast Diseases (metabolism, pathology)
• Breast Neoplasms (chemistry, pathology)
• Cytoplasmic Granules (chemistry)
• Female
• Fibrocystic Breast Disease (metabolism, pathology)
• Humans
• Microscopy, Electron
• Middle Aged
• Serotonin (analysis)
• Silver Staining