Diazepam-induced feeding in captive gray wolves (Canis lupus).

Abstract

Diazepam doses of 0.2, 0.4, and 0.8 mg/kg induced feeding in sated gray wolves in a dose-dependent manner (p less than 0.001). Neither 0.8 mg/kg of the benzodiazepine antagonist, beta-CCP (p = 0.36), nor 0.8 mg/kg of the benzodiazepine inverse agonist, beta-CCE (p = 0.85), decreased the diazepam-induced hyperphagia. Five of 6 naive wolves (p = 0.003) ate dry dog food within 15.4 +/- 1.9 min of being given 0.4 mg/kg diazepam and freely chose dog food after the single diazepam administration.

• Authors: T J Kreeger, A S Levine, U S Seal, M Callahan, M Beckel
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 39 Issue 3 Pg. 559-61 (Jul 1991) ISSN: 0091-3057 [Print] United States
• PMID: 1784584 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Carbolines
• beta-carboline-3-carboxylic acid ethyl ester
• propyl beta-carboline-3-carboxylate
• Diazepam

Topics

• Animals
• Carbolines (pharmacology)
• Carnivora (psychology)
• Diazepam (pharmacology)
• Dose-Response Relationship, Drug
• Feeding Behavior (drug effects)
• Female
• Male
• Satiation (physiology)