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(S)-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity.

Abstract
(S)-9-(2,3-Dihydroxypropyl)adenine, a novel nucleoside analog, the sugar moiety of which is replaced by an aliphatic chain, inhibits the replication in vitro of several DNA and RNA viruses, including vaccinia, herpes simplex (types 1 and 2), measles, and vesicular stomatitis. It is also effective in vivo in reducing the mortality rate of mice inoculated intranasally with vesicular stomatitis virus.
AuthorsE DE Clercq, J Descamps, P DE Somer, A Holyacute
JournalScience (New York, N.Y.) (Science) Vol. 200 Issue 4341 Pg. 563-5 (May 05 1978) ISSN: 0036-8075 [Print] United States
PMID17839440 (Publication Type: Journal Article)

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